Amy (Mila Kunis) has a great husband, overachieving children, beautiful home and successful career. Unfortunately, she's also overworked, exhausted and ready to snap. Fed up, she joins forces with two other stressed-out mothers (Kristen Bell, Kathryn Hahn) to get away from daily life and conventional responsibilities.

As the gals go wild with their newfound freedom, they set themselves up for the ultimate showdown with PTA queen bee Gwendolyn and her clique of seemingly perfect moms.